Dr. Verybad has discovered a new neurodegenerative disease (Verybad disease, VBD).
The disease starts as headaches and muscle weakness and progresses to cognitive
impairment, loss of muscle control, and death. The cause of the disease is currently
unknown and there is no treatment. Dr. Verybad has a hypothesis that this is the result of
a mutation in a gene located on the X chromosome called Don’t Touch This gene 1
(Dtt1). Dr. Verybad wants to sequence the gene to determine if there is a mutation in Dtt1
responsible for the pathogenesis of VBD.
1) If the defect is in Dtt1, what do you predict would be the male to female incidence
of VBD and why? (10 points)
2) If there is a mutation in the sequence approximately 250 base-pairs upstream of
the transcription start sight, what might this mutation be affecting? Propose 1
experiment to investigate this possibility. Explain the protocol, controls, and
expected results. (10 points)
3) If there is a mutation that falls within an intron close to an exon junction, what
might this mutation be affecting? Propose 1 experiment to investigate this
possibility. Explain the protocol, controls, and expected results. (10 points)
4) If there is a mutation within an exon, what might this mutation be affecting?
Propose 1 experiment to investigate this possibility. Explain the protocol,
controls, and expected results. (10 points)
5) If there is a mutation in the 3’ Untranslated region (3’ UTR), what might this
mutation be affecting? Propose 1 experiment to investigate this possibility.
Explain the protocol, controls, and expected results. (10 points)
6) After sequencing the Dtt1 gene, Dr. Verybad found no changes in the gene
sequence. However, he has found that the protein forms aggregates within the
cells that results in plaque formation, neuronal loss, and a spongy look to the brain
tissue. What might the cause of this disease (5 points extra credit, up to a total of
At 111papers.com, we value all our customers, and for that, always strive to ensure that we deliver the best top-quality content that we can. All the processes, from writing, formatting, editing, and submission is 100% original and detail-oriented. With us, you are, therefore, always guaranteed quality work by certified and experienced writing professionals. We take pride in the university homework help services that we provide our customers.
As the best homework help service in the world, 111 Papers ensures that all customers are completely satisfied with the finished product before disbursing payment. You are not obligated to pay for the final product if you aren’t 100% satisfied with the paper. We also provide a money-back guarantee if you don’t feel that your paper was written to your satisfaction. This guarantee is totally transparent and follows all the terms and conditions set by the company.Read more
All products that we deliver are guaranteed to be 100% original. We check for unoriginality on all orders delivered by our writers using the most advanced anti-plagiarism programs in the market. We, therefore, guarantee that all products that we submit to you are 100% original. We have a zero-tolerance policy for copied content. Thanks to our strict no plagiarized work rule, you can submit your homework to your professor without worrying.Read more
TThis is one of the most cherished courtesy services that we provide to help ensure that our customers are completely satisfied with our finished products. Delivering the best final product to our customers takes multiple inputs. 111papers.com prides itself on delivering the best university homework help services in the writing industry. And, in part, our free revision policy is how we do it. What’s more, all our revisions are 100% free without any strings attached.Read more
Client privacy is important to use. We know and understand just how important customers value their privacy and always want to safeguard their personal information. Thus, all the information that you share with us will always remain in safe custody. We will never disclose your personal information to any third party or sell your details to anyone. 111 Papers uses the most sophisticated, top-of-the-line security programs to ensure that our customers’ information is safe and secured.Read more
Placing your order with us means that you agree with the homework help service we provide. We, in turn, will endear to ensure that we do everything we can to deliver the most comprehensive finished product as per your requirements. We will also count on your cooperation to help us deliver on this mandate. Yes, we also need you to ensure that you have the highest-quality paper.Read more