One paragraph debate “benefits” | Biology homework help

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How do transgenic animals contribute to human welfare?

Medical Applications


Transplant organs may soon come from transgenic animals.


a) xenotransplantation 


Patients die every year for lack of a replacement heart, liver, or kidney. For 


example, about 5,000 organs are needed each year in the United Kingdom 


alone.25 Transgenic pigs may provide the transplant organs needed to 


alleviate the shortfall.9 Currently, xenotransplantation is hampered by a pig 


protein that can cause donor rejection but research is underway to remove 


the pig protein and replace it with a human protein.25


Milk-producing transgenic animals are especially useful for medicines.


b) nutritional supplements and pharmaceuticals 


Products such as insulin, growth hormone, and blood anti-clotting factors 


may soon be or have already been obtained from the milk of transgenic 


cows, sheep, or goats.3,12,23 Research is also underway to manufacture milk 


through transgenesis for treatment of debilitating diseases such as 


phenylketonuria (PKU), hereditary emphysema, and cystic fibrosis.3,13,23,25


In 1997, the first transgenic cow, Rosie, produced human protein-enriched 


milk at 2.4 grams per litre. This transgenic milk is a more nutritionally 


balanced product than natural bovine milk and could be given to babies or 


the elderly with special nutritional or digestive needs.4,21,23 Rosie’s milk 


contains the human gene alpha-lactalbumin.


A transgenic cow exists that produces a substance to help human red cells grow.


c) human gene therapy 


Human gene therapy involves adding a normal copy of a gene (transgene) to 


the genome of a person carrying defective copies of the gene. The potential 


for treatments for the 5,000 named genetic diseases is huge and transgenic 


animals could play a role. For example, the A. I. Virtanen Institute in Finland 


produced a calf with a gene that makes the substance that promotes the 


growth of red cells in humans.24

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